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Raman microscopy: a new imaging modality for biology and medicine

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Katsumasa Fujita

Department of Applied Physics, Osaka University, Suita, Osaka, Japan, 565-0871

Email: fujita@ap.eng.osaka-u.ac.jp

 

Raman microscopy harnesses its capability of detecting molecular vibrations  to create distinct contrasts in microscopic images. This unique approach enables label-free imaging, the visualization of small molecules, and comprehensive analyses of cell states, revealing biological insights that remain elusive with traditional methods. In this workshop, attendees will be introduced to the underlying physics of Raman scattering, the foundational principles of Raman microscopy, and its applications in both biological and medical research fields.

Prof. Katsumasa Fujita is Professor of Applied Physics at Osaka University. He obtained the BSc, MSc, and Ph.D. in Applied Physics in 1995, 1997, and 2000, respectively, from Osaka University. After working as a postdoctoral fellow at Kyoto Prefectural University of Medicine, he joined Osaka University as a faculty member in 2002 and was promoted to a full professor in 2018.  He has been working on the development of high-resolution and high-speed Raman imaging techniques for biomedical research, especially using spontaneous Raman scattering. His technique drastically improved the speed of Raman imaging and paved the way to apply hyperspectral Raman imaging for the observation and analysis of biological molecules in living systems. He also demonstrated the use of alkyne, a carbon-carbon triple bond, as a small tag for imaging small molecules by Raman microscopy. He has also been working on the improvement of the spatial resolution in Raman microscopy and reported the first demonstration of super-resolution imaging in both spontaneous Raman and coherent Raman scattering microscopies.

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